Thus, we performed a meta-analysis of 18 randomized controlled trials to reevaluate the efficacy of statin treatment to prevent MI in patients. Therefore, a more comprehensive analysis of benefits of statin for MI is needed. However, other clinical studies showed that early use of statin did not reduce the occurrence of MI. Some studies showed that statin pretreatment is associated with a significant reduction in MI. Therefore, statins are regarded as an important agent for the prevention of MI. Statins is an inhibitor of hydroxymethylglutaryl-CoA reductase, and it is identified to have pleiotropic effects, such as anti-inflammatory and antithrombotic properties and antioxidant effects. The treatment of statins for the prevention of recurrent MI has been demonstrated in several randomized controlled trials. Therefore, the prevention and reconstruction of the occluded artery is the key factor for MI. It suddenly happens in a few minutes when the oxygen supply is blocked, and results in myocardial cell death in a few hours. On the contrary, MI is an emergency and much more serious. The development of CAD is a long-time process that suffered from erosion of endothelium to narrowing of artery. The main nosogenesis is the extensive necrosis of cardiomyocytes caused by prolonged ischemia. Myocardial infarction (MI) is the most serious and fatal result of CAD. The Global Status Report states that cardiovascular disease (CAD) has caused more and more deaths.
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